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For this reason, numerous targeted therapies that can remedy dysregulated TGF- activity have been developed with some demonstrating encouraging safety and efficacy in clinical trials

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A prominent example is hyperactivation of the Wnt/-catenin pathway, which promotes tumor angiogenesis by acting on PDK1

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Considering bioactivity and function of retinoids, many health claims regarding the general population as target group have been proposed and verified as such including vitamin A as a contributor to the maintenance of normal skin, mucous membranes (lung, intestines, nose, eyes), normal vision, cell specialization / differentiation and normal function of the immune system [95]

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